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Next, we sought to compare the levels of 7OH and MP reached when formed as metabolites following mitragynine administration versus those achieved when administered directly at equi-antinociceptive dosing, in order to demonstrate that the metabolites were responsible for antinociception

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4, 10, 35 Isoprostanes, products of lipid peroxidation, are thought to be particularly important in the context of vascular disease, and the measure of this parameter has been projected as a reliable, sensitive, and noninvasive marker of oxidative stress in vivo as well as having relevance to vascular disease