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Preclinical studies have used a range of concentrations, including: In vivo murine models: 5–10 mg/kg (micrograms per kilogram body weight) In vitro cellular assays: 1–20 µM (micromolar concentrations) Note: These concentrations are from FOXO4-DRI preclinical studies only and should not be extrapolated to human or animal use
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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Mosharov E., Cranford M.R., Banerjee R
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